Computational Biology

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction
In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and …
Keqi Wang, Keilung Choy, Eli Reiser, Jinxiang Pei, Hua Zheng, Aparajita Dasgupta, Fuqiang Cheng, Guogang Dong, Bhanu Chandra Mulukutla, Joshua Mannheimer, Carolyn Huang, Hooman Farsani, Wei Xie
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Stochastic biological system-of-systems modelling for iPSC culture
Large-scale manufacturing of induced pluripotent stem cells (iPSCs) is essential for cell therapies and regenerative medicines. Yet, …
Hua Zheng, Sarah W Harcum, Jinxiang Pei, Wei Xie
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Stochastic biological system-of-systems modelling for iPSC culture